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Although there was no significant improvement in glycaemia with efinopegdutide, this was explicable given that the participants had normal glycaemia at baseline

Semaglutide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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Neither formulation is available over the counter and requires a prescription

In contrast, T2DM patients that had not undergone bariatric procedures fully responded to the DPP4 inhibitor with improved glucose tolerance and insulin secretion even when combined with Ex9 (167)
