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GLP-1 receptor agonists are a class of medications that mimic a natural hormone in the body

Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1

Weight loss is targeted at a rate of 1-3 lbs per week and works even for those who have a history of frequent or repeat dieting, weight loss resistance, difficulty maintaining weight loss, sugar and carb cravings, peri-menopausal or post-menopausal weight gain, and poor blood sugar control

342,343,344 The GLP-1R signaling pathway may also affect the expression of MMP-13 and ADAMTS5, by reducing the signal transduction caused by IL-1, thus decreasing their synthesis