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Description
53 Novel triple-G agonists Retatrutide is a novel, once-weekly injectable agent that acts on GIP, GLP-1 and glucagon receptors, and has shown promise in clinical trials for significant weight loss

Reduced appetite is the intended effect, but sometimes it feels too extreme

This mechanism of GLP-1R internalization has been proposed to occur through activation of G q proteins, followed by activation of PKC (Thompson and Kanamarlapudi, 2015)

But intelligently

Nature 573, 281286
