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There are also motility alterations, such as diarrhea explained by the rapid colonic transit, as GLP1 activates intrinsic afferent neurons containing calcitonin gene-related peptide that favors the frequency of peristaltic contractions (158) or constipation due to mechanisms dependent on nitric oxide and AMPc/PKA that reduces colon contractility (159)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Iatan I., Huang K., Vikulova D., Ranjan S., Brunham L.R

Thus, microglial GLP-1Rs play a crucial role in the development of epilepsy

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