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CagriSema and Amycretin work on the GLP-1 and amylin receptors, Retrarutide on GLP-1, GIP and glucagon, Survodutide, Mazdutide, Pemvidutide and Efinopegdutide on GLP-1 and glucagon and still more are coming

Significance statement ![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

Glucagon increases blood glucose levels, particularly during fasting, and facilitates the mobilization of energy reserves.Synthetic agonists like semaglutide and tirzepatide are stable peptides that specifically activate the receptors of these hormones, amplifying their beneficial effects on glycemic control and weight management