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doi: 10.1016/j.jacc.2025.05.024 [DOI] [PubMed] [Google Scholar] 2

Research published in the New England Journal of Medicine (Wilding et al., 2021) demonstrated that semaglutide produced average weight loss of nearly 15 percent of body weight over 68 weeks

Visceral fat is metabolically active in ways that drive insulin resistance, inflammation, and cardiovascular risk

Thus, this modest increase in LDL-C may be misleading regarding ASCVD risk, as patients with obesity may have a higher concentration of atherogenic small, dense LDL particles, and therefore high levels of apoB for a given blood LDL-C [10, 13]

For some patients, that space feels like relief