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By testing a theoretical range of human GLP-1R potencies at a once-weekly 50 mg dose and assuming the peptide retains its activity over the dosing period, simulations showed that a potency 40-fold less than the reference GLP-1-Fc(4) molecule should deliver equivalent GLP-1 activity to a 1.5 mg weekly dose of GLP-1-Fc(4) (Supplementary Fig

The anti-inflammatory effects are a promising additional benefit, not a primary treatment

For patients with pre-existing mild or moderate DR, the effects of GLP-1 drugs could significantly worsen this condition

These medications may also help lower blood pressure, improve lipid disorders and fatty liver disease, slow diabetes-related neuropathy, and reduce the risk of heart and kidney disease

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