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Description

TGR5 inhibition of glycogenolysis in hepatic tissue is dependent on GLP-1 activity, as coadministration of a TGR5 agonist and GLP-1 antagonist abolished the suppression of hepatic glycogenolysis [140]

10 IU = 0.10 ml

Retatrutide is around 6 days, which is why weekly dosing works

Additionally, semaglutide is used to help reduce the risk of stroke, heart attack, and heart disease in people with type 2 diabetes

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