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However, from a practical standpoint, the immediate reduction of appetite is not a universal experience

These agents mimic the action of endogenous GLP-1, an incretin hormone released from intestinal L-cells in response to nutrient intake

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Rosenstock J, Wysham C, Fras JP et al (2021) Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

The new evidence requirements are detailed: certificates of analysis, stability data, validated assay methods, and documented out-of-specification investigation procedures