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Other notable adverse effects include: Injection site reactions such as erythema, pruritus, or swelling Fatigue reported in approximately 5% to 6% of patients Hypoglycemia when used in combination with insulin or sulfonylureas Increased heart rate with modest elevations of 2 to 4 beats per minute (a class effect of incretin therapies with uncertain clinical significance) Serious but rare adverse effects include acute pancreatitis, gallbladder disease (cholelithiasis, cholecystitis), acute kidney injury (typically secondary to dehydration from gastrointestinal symptoms), and hypersensitivity reactions

Conditions like central retinal artery occlusion or optic neuritis may present similarly but require different treatments

Higher scores indicate a better state of health

As more patients and healthcare providers seek effective diabetes management solutions with minimal side effects, demand for GLP-1 receptor agonists is set to surge

Epidemiological evidence from large cohort studies The strongest population-level evidence comes from a study published on medRxiv that compared allodynia incidence between GLP-1 receptor agonist users and users of bupropion-naltrexone, an alternative weight management medication