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Stimulant herbs such as senna and cascara can be a powerful (and somewhat uncomfortable) way to get the bowels moving

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Glucagon receptor activation was initially considered problematic because glucagon raises blood glucose levels

(Reporting by Bhanvi Satija and Puyaan Singh in Bengaluru, and Patrick Wingrove in New York

It took a desert lizard, a Bronx endocrinologist willing to spend his own money on a patent filing, and a Danish insulin company with a very long time horizon to turn the fragile peptide into a shelf-stable weekly injection