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BioMed Central+1 Brain insulin signaling : GLP-1 RAs in animal models can improve insulin signaling in neurons, enhancing glucose uptake and utilization in brain regions affected in AD

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Dysfunction in insulin signaling due to hypoinsulinemia, hyperinsulinemia, or insulin resistance leads to impaired glucose uptake, neurotransmitter imbalance, oxidative stress, mitochondrial dysfunction, ion-channel alterations, neuroinflammation, and disruption of the blood-brain barrier, ultimately enhancing neuronal hyperexcitability and seizure susceptibility