glp 1 moa Mechanism of action for GLP-1R agonists. Primarily expressed in the GLP-1 and the kidney: from

This brilliant JAMA review by Gonzalez-Rellan & Drucker one of the original discoverers of GLP-1 biology

GLP-1 agonists taken once a week typically cause fewer side effects, but no one wants to start with a week of nausea or vomiting

It will be interesting to see how much these medications seem to help with arthritis pain based on weight loss alone versus via other mechanisms

The region benefits from a high prevalence of obesity and type 2 diabetes, advanced healthcare infrastructure, substantial pharmaceutical research and development investments, favorable reimbursement frameworks, and rapid adoption of innovative therapeutic technologies

Verma S, Poulter NR, Bhatt DL et al (2018) Effects of liraglutide on cardiovascular outcomes in patients with type 2 diabetes mellitus with or without history of myocardial infarction or stroke