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Rights and permissions About this article Cite this article Everard, A., Cani, P.D

Difference in sensitivity to central leptin and insulin in male and female rats and the influence of gonadal hormones on their central action is well documented ( 10 )

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Practical nausea management Eat smaller, more frequent meals instead of three large ones

In rats, several studies have shown that native GLP1 administered intraperitoneally (i.p.) requires intact vagal afferents to cause satiation, that is, to reduce meal size (Ruttimann et al., 2009)