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They achieve this by stimulating the pyloric sphincter and reducing peristalsis, which extends the time food remains in the stomach

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doi: 10.1016/j.jalz.2015.07.489

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This helps control cravings and manage food intake, ultimately contributing to weight loss over time

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Although SUMMIT also demonstrated a reduction in the composite endpoint of cardiovascular death or worsening HF events, the magnitude of the improvement, specifically in the KCCQ-CSS observed with higher-dose semaglutide (STEP-HFpEF

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