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Cerebral effects of glucagon-like peptide-1 receptor agonists Independently of the aforementioned peripheral actions, GLP-1RAs also have direct cerebral effects that may contribute to reducing the risk of stroke in patients with T2DM

Berberine, for example, appears to increase GLP-1 secretion through multiple pathways including activation of the TGR5 receptor and modulation of gut microbiota composition

Since obesity is now understood as a metabolic disease, similar to conditions like hypertension or diabetes, medical treatments are often necessary to achieve sustained weight loss

In people with a family history of atrial fibrillation, atrial fibrillation may increase the risk

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