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The glycine and B12 rationale applies equally to both medications

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice

Herbal and nutritional supplements Certain herbs and supplements can support the mechanisms of GLP-1 drugs: Berberine: Helps regulate blood sugar and supports gut health Cinnamon: Enhances insulin sensitivity Apple cider vinegar: Can reduce post-meal glucose spikes Adaptogens: Maca, Rhodiola, and Holy Basil help modulate stress and hormonal balance Detoxification and environmental health Reducing exposure to endocrine-disrupting chemicals in plastics, pesticides, and personal care products is vital for your hormonal and metabolic health and weight loss

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Do they actually make a difference