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Starting with a low dose, such as 1 mg or 2 mg weekly, and gradually increasing to higher doses like 4 mg, 8 mg, or 12 mg may help reduce these effects

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Individual response varies significantly based on genetics, baseline metabolic rate, and adherence

To better understand how Tko may use inteins, we are constructing genetically modified variants with individual intein deletions to see the effects on replication strategy and cellular fitness

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