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Description
Other hits provide evidence of downstream effects on the liver (IGFBP-2, GDF-15) and pancreas (REG1A, SPINK1)

Moreover, dosing rats with GLP-1 stimulates the production of LH in female rats, which triggers ovulation in rats and humans (46)

Specific alleles in FTO and MC4R may indicate baseline metabolic rate and appetite-regulation capacity

Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B: Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression

doi:10.1056/NEJMoa2032183 95