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Even though additional physicochemical properties play important roles, placental transfer of drugs with such high molecular size is generally not anticipated in the first trimester of pregnancy, unless a specific mechanism for transfer exists

For male patients, limited data suggest potential improvements in testosterone levels in men with obesity and hypogonadism, likely secondary to weight loss and reduced aromatase activity in adipose tissue

What to Expect with GLP-1 Agonists GLP-1 agonists have shown impressive results for weight loss in patients with PCOS, with benefits that continue to improve over time

(By comparison, Novo Nordisks best-seller Wegovy/Ozempic brings in similar multi-billion revenues, but Lillys CAGR in recent quarters has been higher.) Analysts attribute Lillys success to tirzepatides superior weight loss in trials and aggressive marketing