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Key Points: GI symptoms are the most common adverse effects, ranging from expected nausea and vomiting to gastroparesis and, rarely, functional obstruction Delayed gastric emptying has important airway implications and a cautious approach to airway management is warranted Biliary disease is one of the most clinically significant complications, particularly early in treatment and with rapid weight loss Pancreatitis is rare, and current evidence does not support a strong causal relationship EDKA and AKI are uncommon but important to recognize in the right context Conclusions: GLP-1 receptor agonists have transformed the management of diabetes and obesity, with clear benefits in weight loss, glycemic control, and cardiovascular outcomes

Stombaugh says

Many patients and doctors consider it a starting point when newer agents are unavailable or too expensive

Reviewing your tirzepatide dose, protein intake, physical activity, sleep quality, and overall treatment plan with your healthcare provider can often help restart weight loss
Frequently Asked Questions Can GLP-1 agonists reverse leptin resistance
