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How these medications cause weight loss when combined is still somewhat of a mystery, but experts theorize that the combo touches the brains reward centers: Bupropion affects the pathways of two neurotransmitters, dopamine and norepinephrine, which are used in brain areas that process appetite and reward, and naltrexone tends to boost and reinforce this effect, Maselli says

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GLP-1 Success A better GLP-1 journey starts here *Eligible patients lost an average of 21% of their body weight (-48 lbs) in a 72-week clinical trial evaluating 15 mg tirzepatide, when paired with diet and exercise

From the gate go of the case, they have been on top of everything

Exercise, nutrition habits, metabolism, and starting body weight may also influence how quickly weight loss occurs
