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For GLP-1 drugs for diabetes, Blue Cross utilization management procedures ensure that members who have type 2 diabetes are the only members who use these products

Temporary dose reductions during particularly symptomatic periods, followed by re-escalation once symptoms stabilize, represents a common clinical approach

[6] Regulatory bodies including the MHRA and EMA have included pancreatitis as a potential adverse effect in the prescribing information for GLP-1 agonists

These are medications like Semaglutide (the active ingredient in Ozempic and Wegovy) and Tirzepatide (the active ingredient in Mounjaro and Zepbound)

The triple-agonist mechanism does not appear to produce dramatically worse stomach pain than single-agonist GLP-1 compounds