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Jumping directly to a high dose or splitting injections defeats this protective strategy and often results in more discomfort without better results

To summarize these mechanisms and their corresponding efficacy with GLP-1RAs or GLP-1, GLP-1RAs show the endothelial protective properties and thus owe to modulating vascular tone and maintaining endothelial barrier integrity, as well as the anti-adhesive and anti-thrombotic actions

a Clinicaltrials.gov identifier ( Table 2 Summary of Clinical Trials in Which the Cardiovascular Effects of GLP-1 RAs Were Non-Primary Outcomes GLP-1 RA, glucagon-like peptide-1 receptor agonist