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Their effects often emerge only in specific physiological contexts, such as exercise, growth, or aging, and may depend on coordinated signaling across multiple tissues

If the reduction in body weight and the improvement of glycemic control are crucial factors in determining the effects of GLP-1 on NAFLD, direct pharmacological mechanisms could also be involved

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After 8 weeks of the HFD, the HFD + NaB group underwent daily intragastric administration of NaB at 200 mg/kg body weight for 8 weeks, while the HFD group received the same amount of saline daily for 8 weeks

Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
