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Month 1: Women : 1.5 mg once weekly Men : 1.8 mg once weekly Month 2: Women: 3 mg once weekly (compared to the standard 5 mg) Men : 3.6 mg once weekly (compared to the standard 5 mg) Month 3: Women : 4.5 mg once weekly (instead of the standard 7.5 mg) Men : 5.4 mg once weekly (instead of the standard 7.5 mg) Doses can be gradually increased while remaining below standard titration levels

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This decrease in energy expenditure makes continued weight loss more difficult

PlexusDx patients interested in exploring personalized, evidence-based weight loss regimens can consult with their clinical team about whether combination approaches align with their metabolic profile, genetic predispositions, and health goals

The goal is to achieve the metabolic signaling of a stressed cell (GDF15) while maintaining the structural integrity of an active one (Apelin)