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Small vessel disease of not only the heart but also the eye is an evolving field of research
Although case reports have described levothyroxine over-replacement and subsequent AF/Aflutter following GLP-1RA initiation [37], no largescale study has evaluated the real-world effect of GLP-1RA initiation on cardiovascular outcomes

Patients considering low-dose GLP-1 therapy should undergo thorough evaluation, including assessment of contraindications, baseline inflammatory markers if appropriate, and regular monitoring for adverse effects

Some studies indicate these drugs can reduce cocaine self-administration and relapse-like drug seeking

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