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Two authors (DM and SS) independently reviewed and selected studies for inclusion and subsequently resolved discrepancies by discussion

The success of GLP-1 (Glucagon-like peptide-1) drugs, such as semaglutide and liraglutide, in treating alcohol and substance use disorders (ASUDs) is primarily explained by their ability to modulate key neurobiological pathways involved in addiction

We expect oral forms to become more common over time

Dehydration exacerbates nausea, causes headaches (often misattributed to the peptide itself), and can lead to dizziness and lightheadedness

CLINICAL DOSING USED IN STUDIES Based on published clinical protocols for Thera/ Tirzepatide : Dose Escalation (Titration Schedule) Gradual titration is used to improve gastrointestinal tolerability