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Jastreboff et al., NEJM, 2022 (SURMOUNT-1) Dramatically Improves Metabolic Health Tirzepatide leads to significant improvements in blood sugar, insulin sensitivity, and cholesterol, powerfully addressing the metabolic dysfunction that drives aging

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In a Phase II trial, patients in the Mazdutide group saw a weight decrease between 5% and 22.5%, with a notable proportion of patients across different dosage groups achieving at least a 10% or even higher degree of weight reduction