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Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]

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Dose titration is standard practice to improve tolerability

Keep in mind that some medications for these conditions such as insulin, sulfonylureas, or certain beta-blockers can contribute to weight gain

But fear not, because just like any star in Hollywood, there are ways to manage these side effects and keep the show going