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It is clarified that guanfacine is not a prohibited substance

There are emerging/established benefits for cardiovascular disease, heart failure, chronic kidney disease, sleep apnoea, osteoarthritis, and metabolic-associated steatotic liver disease [8]
326 , E472E480 (2024)

According to research on medication routes of administration, when medications dissolve under the tongue or in the cheek, they undergo passive diffusion through the venous blood in the oral cavity, which bypasses the hepatic portal vein and flows directly into systemic circulation

These medications are prescribed for a range of conditions and their growing use reflects both clinical need and cultural momentum