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The majority of previous studies suggest that cannabis use acutely stimulates appetite and food intake, while chronic cannabis use reduces the risk of obesity, insulin resistance, and diabetes mellitus 25,65,66,67,68

The potential benefits of semaglutide 1 mg once weekly in people with atherosclerosis and peripheral artery disease (Figs 3, 4) are being examined over 52 weeks, with the primary outcomes of treadmill walking distance and secondary outcomes of changes in quality of life and pain free walking distance (NCT04560998)

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If rapid pain relief is required, this minor delay is unlikely to pose problems for most individuals