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GLP-1 medications have made headlines for their effects on diabetes and obesity

GLP-1 receptor agonists are not recommended during pregnancy due to limited human safety data and animal study findings
Prices for semaglutide and tirzepatide drugs are higher in the U.S

This is all well and good for people with obesity (PwO) who also have diabetes, but what if Mr T had obesity without diabetes

We evaluated the effects of metformin, administered at different intervals before an intraduodenal glucose infusion, on the subsequent glycaemic, insulinaemic and GLP-1 responses in metformin-treated type 2 diabetes
