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Some people cannot tolerate the medication, have health conditions that make it unsuitable, or need a different approach

Because these therapies are often introduced gradually, many people notice more significant effects over time as doses increase and the body adjusts

Pillar 6: Pioglitazone (PPAR-gamma agonist) Pioglitazone can improve insulin sensitivity partly by redistributing fat away from ectopic depots (liver and muscle) towards safer subcutaneous stores

Severe chills, uncontrollable shivering, or cold sensitivity paired with dizziness, rapid heartbeat, or extreme fatigue requires immediate evaluation
