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Tirzepatide may not be appropriate for all patients, and comorbidities can influence response

At the end of six months, most patients have lost approximately 45% of their excess weight

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However, in rats, GLP-1 elevation of BP is preserved upon pretreatment with reserpine, propanolol or phentolamine, thus indicating that the hypertensive effect of GLP-1 does not exclusively depend on catecholamine signaling [634]