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Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs

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A team from Harvard University started looking into the possible link after three people taking semaglutide the active ingredient in Ozempic and Wegovy were diagnosed with non-arteritic anterior ischemic optic neuropathy (NAION) within a week

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Ross DS, Litofsky D, Ain KB, Bigos T, Brierley JD, Cooper DS, Haugen BR, Jonklaas J, Ladenson PW, Magner J, Robbins J, Skarulis MC, Steward DL, Maxon HR, Sherman SI