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Reduced levels of the mitochondrial autophagy-associated protein Parkin in the substantia nigra may contribute to the development of Parkinsons disease (PD) in db/db mice and high-fat diet-induced diabetic mice

However, like other drugs in its class, tirzepatide shares a similar safety profile, with specific side effects that patients should be aware of

Raz I., Hanefeld M., Xu L., et al., Efficacy and Safety of the Dipeptidyl Peptidase4 Inhibitor Sitagliptin as Monotherapy in Patients With Type 2 Diabetes Mellitus, Diabetologia 49 (2006): 25642571

November 30, 2023