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Research presented at the ACR Convergence 2025 conference showed that RA patients with elevated BMI who took GLP-1 receptor agonists experienced superior improvements in disease activity scores, pain levels, and weight loss compared to controls

Furthermore, the role of the GLP-1R/PI3K/AKT signaling pathway was also demonstrated in BMSC experiments

SM: shanzhiside methylester, IL-10: interleukin-10

5- other GLP-1 trials in Parkinsons have been statistically negative or the results unclear, 6- the study was conducted in only very early Parkinsons cases, 7- the data, if replicable, may not be generalizable to all GLP-1 agonist drugs or to all subtypes of Parkinsons, and 8- the drug Lixisenatide requires a DAILY injection