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On the Alzheimers side, amyloid PET and plasma p-tau217 now do real work at the front door of trials, confirming that enrolled participants actually carry the pathology in question, as the amyloid-confirmed EVOKE cohorts illustrate

One of the most extensive studies to date, performed by the Diabetes Prevention Program (DPP) and published in 2012, tested metformin in people with prediabetes

doi: 10.1016/j.tcm.2015.10.004 19

Behavioral problems included aggressive behavior, which resulted in treatment with risperidone being initiated at the age of 12 years

Future studies could apply single-cell profiling before and after GLP-1RA treatment to see which microglial or astrocyte states are shifted
