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Or will they improve response to therapy

Bethel MA, Diaz R, Castellana N, et al

The SURMOUNT-1 trial showed participants lost up to 22.5% of their body weight on tirzepatide

On the contrary, the American Gastroenterological Association (AGA) advises an individualized approach, stating that more data are needed to decide if and when the GLP-1 RAs should be held prior to elective endoscopy

A study published in Diabetes, Obesity and Metabolism (Frias et al., 2021) from an early phase 2 comparison found that tirzepatide produced dose-dependent weight loss that exceeded semaglutide 1 mg across all dose levels tested, confirming the advantage of the dual mechanism