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Semaglutide targets one hormone involved in appetite regulation (GLP-1), while tirzepatide targets two hormones (GLP-1 and GIP)

CrossRef Effect of ipragliflozin on liver enzymes in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials Rizwana Parveen, Shadan Hussain, Sparsh Saini, Parvej Khan, Nilanjan Saha, Nidhi Expert Opinion on Pharmacotherapy.2024

And a 2010 study in the journal Nutrition Research found that when mildly overweight, healthy women took saffron extract another Lemme ingredient they snacked less, which could help with some weight loss

This collaborative approach optimizes therapeutic outcomes while minimizing potential risks

Going forward, pharma teams that proactively adapt their market-access playbook to this constrained environment will be best positioned to capture the opportunity of the GLP-1 revolution while serving patient needs