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Their potential for disease modification and symptom relief, particularly in specific phenotypes, supports their further exploration as part of a personalized treatment approach.

While the overall frequency of liver enzyme elevations across the over 1,400 participant safety database of danuglipron is in-line with approved agents in the class, a single asymptomatic participant in one of the dose-optimization studies experienced potential drug-induced liver injury which resolved after discontinuation of danuglipron

Results Reducing dose frequency does not commensurately reduce weight loss

It's more effective than semaglutide (a single GLP-1 agonist) for weight loss and blood sugar control

In clinical trials, it led to a weight reduction of up to 16.2%