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This could be a sign of acute pancreatitis, which is serious and potentially life-threatening. The patient information leaflet already included a caution that patients should talk to their doctor, pharmacist or nurse before using Mounjaro if they had ever had pancreatitis (i.e

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Maintain steady hydration to counter dryness tied to nausea and hydration changes during weight loss

Alcohol is, by itself, a gastrointestinal irritant

Early Response Indicators: Early reductions in fasting serum glucose [8] and body weight with tirzepatide were associated with better long-term metabolic outcomes, suggesting that early response may inform treatment individualization