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Conversely, for patients at risk of cancers where GLP1R expression is protective, GLP-1 receptor agonists could be considered a beneficial option

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Advance to the next dose tier only after four consecutive weeks at the current dose with all four tolerability criteria met

Semaglutide activates glucagon-like peptide-1 receptors to reduce hunger and slow stomach emptying, while topiramate acts on multiple brain regions involved in appetite control and energy expenditure

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