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In particular, the GH 24 h secretion is decreased, along with the reduction of insulin-like growth factor I (IGF-I) production and a lower response of GH to stimulation tests [44]
It is not an inevitable trade-off of the weight loss process
At the same time, some epidemiological studies do show that GLP-1RAs can have a protective effect, delaying the progression of dementia in the treatment of patients with T2DM
Tirzepatide targets two receptors (GLP-1, GIP) and produced 22.5% weight loss
So loss in skeletal muscle (when it occurs) is more an indirect effect
