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Stress management techniques warrant consideration, as chronic stress activates the hypothalamic-pituitary-adrenal axis and can increase cortisol levels, which may intensify food cravings, particularly for high-calorie comfort foods

The evidence base for these medications, across metabolic, cardiovascular, and hepatic outcomes, is compelling and growing

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Patients with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe gastroparesis, active pancreatitis, or who are pregnant or planning pregnancy are generally not candidates for GLP-1 therapy

Ji L, Jiang H, Cheng Z, et al