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GLP-1 receptor agonists are a class of medications originally developed and licensed for the treatment of type 2 diabetes mellitus, with some formulations also approved by the MHRA for weight management in adults with obesity or overweight with weight-related comorbidities, under specialist services as per NICE guidance (TA875)

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GLP-1 medications are most commonly delivered through subcutaneous injections, which means theyre injected into the fatty tissue just beneath the skin

Similarly, large observational studies with robust methods for outcomes assessment (thyroid cancer and subtypes), analysis of confounders and comparisons between different agents in the GLP-1 RA class could help identify differences in associated risks for thyroid cancer

The TSA conducted in our study revealed that the limited number of participants may have contributed to the non-significant findings for all-cause mortality