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The first one is metabolic decompensation in infancy (3 months to 2 years) with episodes of hypoketotic hypoglycaemia, hepatomegaly, lethargy, feeding difficulties, elevated hepatic aminotransferase levels and hypoammonemia (induced by fasting or illness, among other things)

[DOI] [PubMed] [Google Scholar] 15.Chirinos J.A., Gurubhagavatula I., Teff K., Rader D.J., Wadden T.A., Townsend R., Foster G.D., Maislin G., Saif H., Broderick P., et al

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5 mg weekly: Average 16% total body weight reduction over 72 weeks 10 mg weekly: Average 21.4% total body weight reduction 15 mg weekly: Average 22.5% total body weight reduction Placebo: Average 2.4% reduction These are remarkable numbers

Gene expression analysis revealed upregulation of thermogenic markers in white adipose tissue, including uncoupling protein 1 (UCP1), which is characteristic of brown adipose tissue