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[14] These pose unpredictable and potentially life-threatening risks when combined with prescription medications like fluoxetine

Two years later, Novo had still failed to pay and the Canadian government let the patent lapse in 2020

Additionally, the study looked at cardiovascular outcomes as a pre-specified secondary analysis which included a four-point composite endpoint of cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina