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In Phase 2 clinical trials, participants achieved 24.2% average weight loss at 48 weeks, the highest result ever recorded for an obesity medication in clinical testing

Extended titration, where you stay at a lower dose for longer before increasing, is the evidence-based approach to managing GI side effects and may solve your problem without any experimental modifications

However, the market is now diversifying beyond incretin pathways toward alternative mechanisms such as CB1 antagonists, MC4R agonists, and myostatin/activin inhibitors

Some people even alternate between both, which can be particularly frustrating